• Lyme disease affects an estimated 300,000 people per year in the United States.

  • Lyme disease is divided into

    • Early disease (erythema migrans [EM])

    • Early disseminated disease (multiple EM lesions, Bell palsy, meningitis, carditis)

    • Late disease (arthritis)

  • EM should be diagnosed clinically, as laboratory test results may be negative.

  • Serology should be considered for the diagnosis of disseminated or late disease only in children with compatible clinical symptoms.

  • Lyme disease has an excellent prognosis if treated with appropriate antibiotics.

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