• Sending bone aspirate/biopsy specimens in addition to blood cultures increases yield of the causative organism, helping to tailor and optimize antibiotic therapy.

  • Consider Kingella kingae as etiology in children younger than 5 years, especially if they do not respond to initial antibiotic therapy for gram-positive bacteria.

  • Completing a course with oral antibiotics does not lead to treatment failure and is appropriate in most cases.

  • A 3- to 4-week total antibiotic course (intravenous [IV] and oral combined) is adequate for most healthy children with an uncomplicated course.

  • Neonates are at higher risk for developing complicated disease with sequalae.

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