Sending bone aspirate/biopsy specimens in addition to blood cultures increases yield of the causative organism, helping to tailor and optimize antibiotic therapy.
Consider Kingella kingae as etiology in children younger than 5 years, especially if they do not respond to initial antibiotic therapy for gram-positive bacteria.
Completing a course with oral antibiotics does not lead to treatment failure and is appropriate in most cases.
A 3- to 4-week total antibiotic course (intravenous [IV] and oral combined) is adequate for most healthy children with an uncomplicated course.
Neonates are at higher risk for developing complicated disease with sequalae.