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DULoxetine

Basics

Name

DULoxetine

Pronunciation

(doo LOX e teen)

Brand Names: US

  • Cymbalta
  • Drizalma Sprinkle

Therapeutic Category

  • Antidepressant, Serotonin/Norepinephrine Reuptake Inhibitor

Medication Safety Issues

Sound-alike/look-alike issues:

Cymbalta may be confused with Symbyax.

Drizalma may be confused with Drisdol, Drisdan.

DULoxetine may be confused with Dexilant, FLUoxetine, PARoxetine, vortioxetine.

Older Adult: High-Risk Medication:

Beers Criteria: Serotonin/Norepinephrine Reuptake Inhibitors (SNRIs) (duloxetine) are identified in the Beers Criteria as potentially inappropriate medications to be used with caution in patients 65 years and older due to their potential to cause or exacerbate syndrome of inappropriate antidiuretic hormone secretion (SIADH) or hyponatremia; monitor sodium concentration closely when initiating or adjusting the dose in older adults (Beers Criteria [AGS 2023]).

Duloxetine is identified in the Screening Tool of Older Person's Prescriptions (STOPP) criteria as a potentially inappropriate medication in older adults (≥65 years of age) with urinary urgency, urge incontinence, severe hypertension, or recurrent falls (O’Mahony 2023).

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