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Zolpidem

Basics

Name

Zolpidem

Pronunciation

(zole PI dem)

Brand Names: US

  • Ambien
  • Ambien CR
  • Edluar
  • Intermezzo [DSC]
  • Zolpimist

Therapeutic Category

  • Nonbenzodiazepine Benzodiazepine Receptor Agonist

Medication Safety Issues

Sound-alike/look-alike issues:

Ambien may be confused with Abilify, Ativan, Ambi 10

Sublinox may be confused with Suboxone

Zolpidem may be confused with lorazepam, zaleplon, Zyloprim

Older Adult: High-Risk Medication:

Beers Criteria: Zolpidem, a nonbenzodiazepine benzodiazepine-receptor agonist hypnotic, is identified in the Beers Criteria as a potentially inappropriate medication to be avoided in patients 65 years and older (independent of diagnosis or condition) due to adverse events similar to benzodiazepines in older adults (eg, delirium, falls, fractures) and an increase in emergency room visits, hospitalizations, and motor vehicle crashes. In addition, improvement in sleep latency and duration is minimal (Beers Criteria [AGS 2019]).

Pharmacy Quality Alliance (PQA): Zolpidem (when cumulative day supply is >90 days) is identified as a high-risk medication in patients 65 years and older on the PQA’s, Use of High-Risk Medications in the Elderly (HRM) performance measure, a safety measure used by the Centers for Medicare and Medicaid Services (CMS) for Medicare plans (PQA 2017).

International issues:

Ambien [US, Argentina, Israel] may be confused with Amyben brand name for amiodarone [Great Britain]

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