Skip to Main Content
Skip Nav Destination






(pa ROKS e teen)

Brand Names: US

  • Brisdelle [DSC]
  • Paxil
  • Paxil CR
  • Pexeva

Therapeutic Category

  • Antidepressant, Selective Serotonin Reuptake Inhibitor (SSRI)

Medication Safety Issues

Sound-alike/look-alike issues:

PARoxetine may be confused with DULoxetine, FLUoxetine, PACLitaxel, piroxicam, pyridoxine, vortioxetine

Paxil may be confused with Doxil, PACLitaxel, Plavix, PROzac, Taxol, Trexall

Pexeva may be confused with Lexiva

Older Adult: High-Risk Medication:

Beers Criteria: Paroxetine is identified in the Beers Criteria as a potentially inappropriate medication to be avoided in patients 65 years and older (independent of diagnosis or condition) due to its strong anticholinergic properties and potential for sedation and orthostatic hypotension. In addition, use the SSRIs with caution due to their potential to cause or exacerbate syndrome of inappropriate antidiuretic hormone secretion (SIADH) or hyponatremia; monitor sodium closely with initiation or dosage adjustments in older adults (Beers Criteria [AGS 2019]).

Pharmacy Quality Alliance (PQA): Paroxetine (alone or in combination) is identified as a high-risk medication in patients 65 years and older on the PQA’s, Use of High-Risk Medications in the Elderly (HRM) performance measure, a safety measure used by the Centers for Medicare and Medicaid Services (CMS) for Medicare plans (PQA 2017).

This item requires a subscription. For full access to this content, please log in to an existing user account or purchase an individual subscription. If you have an active subscription and appear logged in (your name appears in the upper right corner), but you cannot access content, please click the “Log Out” option under your name and log back in.
Close Modal

or Create an Account

Close Modal
Close Modal