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Topiramate

Basics

Name

Topiramate

Pronunciation

(toe PYRE a mate)

Brand Names: US

  • Eprontia
  • Qudexy XR
  • Topamax
  • Topamax Sprinkle
  • Trokendi XR

Therapeutic Category

  • Antiseizure Agent, Miscellaneous

Medication Safety Issues

Sound-alike/look-alike issues:

Topamax may be confused with Sporanox, TEGretol, TEGretol-XR, Toprol-XL

Older Adult: High-Risk Medication:

Topiramate is identified in the Screening Tool of Older Person's Prescriptions (STOPP) criteria as a potentially inappropriate medication in older adults (≥65 years of age) with recurrent falls (O’Mahony 2023).

Administration issues:

Bioequivalence has not been demonstrated between Trokendi XR and Qudexy XR.

Qudexy XR capsules may be swallowed whole or opened to sprinkle the entire contents on a small amount (~1 teaspoon) of soft food. Do not open and sprinkle Trokendi XR capsules on food, chew, or crush; doing so may disrupt the triphasic release properties.

Avoid alcohol use with Trokendi XR within 6 hours prior to and 6 hours after administration; concurrent use may result in dose dumping.

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