Therapeutic Category
- Anti-Parkinson's Agent
- Anticholinergic Agent
- Antidote, Drug-induced Dystonic Reactions
Medication Safety Issues
Sound-alike/look-alike issues:
Trihexyphenidyl may be confused with trifluoperazine
Older adult: High-Risk Medication:
Beers Criteria: Trihexyphenidyl is identified in the Beers Criteria as a potentially inappropriate medication to be avoided in patients 65 years and older due to its highly anticholinergic properties. It is not recommended for the prevention or treatment of extrapyramidal symptoms with antipsychotics. In the treatment of Parkinson disease, more effective agents are available (Beers Criteria [AGS 2023]).
