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Ecallantide

Basics

Name

Ecallantide

Pronunciation

(e KAL lan tide)

Brand Names: US

  • Kalbitor

Therapeutic Category

  • Kallikrein Inhibitor

Generic Availability (US)

No

Index Terms

  • DX-88

Clinical Pharmacology

Mechanism of Action

Ecallantide is a recombinant protein which inhibits the conversion of high molecular weight kininogen to bradykinin by selectively and reversibly inhibiting plasma kallikrein. Unregulated bradykinin production is thought to contribute to the increased vascular permeability and angioedema observed in HAE.

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