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Tecovirimat

Basics

Name

Tecovirimat

Pronunciation

(TEK oh VIR i mat)

Brand Names: US

  • Tpoxx

Therapeutic Category

  • Antiviral Agent

Generic Availability (US)

No

Index Terms

  • Tpoxx, ST-246

Clinical Pharmacology

Mechanism of Action

Tecovirimat inhibits the activity of the orthopoxvirus VP37 protein and blocks its interaction with cellular Rab9 GTPase and TIP47, preventing formation of egress-competent enveloped virions (necessary for dissemination of virus).

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