Anttila
M
,
Eskola
J
,
Ahman
H
,
Kayhty
H
J Infect Dis.
177
1998
1614
1621

To assess possible differences in avidity maturation of antipneumococcal polysaccharide (PS) antibodies between infants boosted with the conjugate and those boosted with the PS vaccine.

Seventy-five healthy infants were vaccinated, and sera were analyzed from 71 infants.

Infants were immunized at 2, 4, and 6 months of age with pneumococcal PS-diphtheria toxoid conjugate vaccine, and boosted at 14 months with the homologous conjugate or a pneumococcal PS vaccine. Relative avidity of immunoglobulin G (IgG) to Streptococcus pneumoniae type 6B and 23F PSs was measured in sera of these children using an EIA and the chaotropic agent thiocyanate. Sera were also analyzed from previous immunogenicity studies in another group of infants primed and boosted with pneumococcal PS-meningococcal protein conjugate and compared with a group boosted with PS vaccine after priming with the pneumococcal...

You do not currently have access to this content.