The Crigler-Najjar syndrome was first described in this journal in 1952. The majority of patients died with kernicterus during the neonatal period. In 1958, the use of phototherapy to treat neonatal jaundice was first reported in England. This therapy was not adopted in the United States until 1968 when the first randomized controlled trial to prevent neonatal jaundice was reported, also in this journal.Little attention was paid to the first reports that phototherapy could be used to modify neonatal hyperbilirubinemia in Crigler-Najjar patients.,5  Over the next 20 years, it became apparent that this is an effective, if inconvenient, therapy. An increasing number of Crigler-Najjar patients now survive into adolescence. The syndrome can be “cured” by hepatic transplants first conducted in 1986. The enzymatic defect in the liver was identified in 19577 and the locus of the missing gene in 1992. Advancements...

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