In the February 2001 issue of Pediatrics, Chase et al describe the utility of the MiniMed continuous subcutaneous glucose monitoring system (CGMS) in detecting unrecognized nocturnal hypoglycemia among children with type 1 diabetes. The interpretations of the results and the conclusions of this study have given us some reservations.

First, the ability of the MiniMed CGMS to accurately detect hypoglycemia is very limited, according to the official manual of MiniMed (chapter 2, Performance Characteristics). In a multicenter clinical trial that involved 62 participants, a total of 1511 CGMS glucose values were compared with readings simultaneously obtained by home glucose meter (ie, reference values). Of the 75 reference values in the low range (<56 mg%), 66.7% were identified by the sensor (hence, a sensitivity of 66.7%). Of the 169 sensor readings in the low range, 29.6% were confirmed by the reference meter, while 70.4% of the sensor readings were actually...

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