Prevention of early vitamin K deficiency bleeding (VKDB) of the newborn, with onset at birth to 2 weeks of age (formerly known as classic hemorrhagic disease of the newborn), by oral or parenteral administration of vitamin K is accepted practice. In contrast, late VKDB, with onset from 2 to 12 weeks of age, is most effectively prevented by parenteral administration of vitamin K. Earlier concern regarding a possible causal association between parenteral vitamin K and childhood cancer has not been substantiated. This revised statement presents updated recommendations for the use of vitamin K in the prevention of early and late VKDB.
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American Academy of Pediatrics| July 01 2003
Committee on Fetus and Newborn; Controversies Concerning Vitamin K and the Newborn. Pediatrics July 2003; 112 (1): 191–192. 10.1542/peds.112.1.191
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