A cluster of 5 family members, a mother and 4 children, were hospitalized for severe group A Streptococcus (GAS) pneumonia. Three family members had complications: sepsis (1), empyema (2), and a sterile parapneumonic effusion (1). Two additional family members had symptoms of upper respiratory tract infection, and 1 was hospitalized for these symptoms. GAS was isolated from the blood of 1 patient, the pleural fluid of 2 patients, and the oropharynx of 6 patients. Pulsed field gel electrophoresis testing revealed an identical deoxyribonucleic acid pattern in all 7 isolates. Genotyping revealed the speA gene and serotyping the T-1, M-1 serotype in all isolates. This family cluster of invasive GAS disease is the largest reported to date, with an attack rate of 41.7% (5 of 12 family members). This report provides further support for antibiotic prophylaxis of close contacts of individuals with invasive GAS disease.
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July 2003
Electronic Articles|
July 01 2003
A Family Cluster of Five Cases of Group A Streptococcal Pneumonia
Sumita Roy, MD;
Sumita Roy, MD
*Department of Pediatrics, Rainbow Babies and Children’s Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio
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Edward L. Kaplan, MD;
Edward L. Kaplan, MD
‡World Health Organization Collaborating Center for Reference and Research on Streptococci, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota
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Benigno Rodriguez, MD;
Benigno Rodriguez, MD
§Department of Medicine University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio
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John R. Schreiber, MD, MPH;
John R. Schreiber, MD, MPH
*Department of Pediatrics, Rainbow Babies and Children’s Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio
∥Department of Pathology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio
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Robert A. Salata, MD;
Robert A. Salata, MD
§Department of Medicine University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio
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Elizabeth Palavecino, MD;
Elizabeth Palavecino, MD
∥Department of Pathology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio
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Chandy C. John, MD, MS
Chandy C. John, MD, MS
*Department of Pediatrics, Rainbow Babies and Children’s Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio
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Address correspondence to Chandy C. John, MD, MS, Division of Pediatric Infectious Disease, Rainbow Babies and Children’s Hospital, RBC 487, 11100 Euclid Ave, MS6008, Cleveland, OH 44106. E-mail: ccj@cwru.edu
Pediatrics (2003) 112 (1): e61–e65.
Article history
Received:
December 26 2002
Accepted:
March 18 2003
Connected Content
A correction has been published:
ERRATUM
Citation
Sumita Roy, Edward L. Kaplan, Benigno Rodriguez, John R. Schreiber, Robert A. Salata, Elizabeth Palavecino, Chandy C. John; A Family Cluster of Five Cases of Group A Streptococcal Pneumonia. Pediatrics July 2003; 112 (1): e61–e65. 10.1542/peds.112.1.e61
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