Infantile vitamin B12 (vit B12) deficiency is encountered in malnourished infants or in offspring of strict vegan mothers or mothers with pernicious anemia and accompanied by hematologic and neurologic findings. We present here a 16-month-old infant whose mother had vit B12 deficiency with low socioeconomic level admitted to our hospital. On admission, the patient was apathic, hypotonic, and lethargic. Serum vit B12 level was below detectable limits. On cranial magnetic resonance imaging (MRI), T2-weighted images revealed bilateral frontal and parietal periventricular high-signal symmetric lesions in the white matter (delayed myelination) and frontoparietal cortical atrophy. On day 3 of vit B12 therapy, involuntary movements were observed.

Vit B12 is an essential vitamin and needs to be supplied by diet. Although a vit B12-deficient diet can be tolerated by the adults for years from the endogenous pool, deficiency in infants may become symptomatic...

You do not currently have access to this content.