Vaccines often contain preservatives, adjuvants, additives, or manufacturing residuals in addition to pathogen-specific immunogens. Some parents, alerted by stories in the news media or information contained on the World Wide Web, are concerned that some of the substances contained in vaccines might harm their children. We reviewed data on thimerosal, aluminum, gelatin, human serum albumin, formaldehyde, antibiotics, egg proteins, and yeast proteins. Both gelatin and egg proteins are contained in vaccines in quantities sufficient to induce rare instances of severe, immediate-type hypersensitivity reactions. However, quantities of mercury, aluminum, formaldehyde, human serum albumin, antibiotics, and yeast proteins in vaccines have not been found to be harmful in humans or experimental animals.
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Special Articles| December 01 2003
Addressing Parents’ Concerns: Do Vaccines Contain Harmful Preservatives, Adjuvants, Additives, or Residuals?
Paul A. Offit, MD;
Reprint requests to (P.A.O.) Division of Infectious Diseases, Children’s Hospital of Philadelphia, Abramson Research Building, Rm 1202C, 34th St and Civic Center Blvd, Philadelphia, PA 19104. E-mail: email@example.com
Paul A. Offit, Rita K. Jew; Addressing Parents’ Concerns: Do Vaccines Contain Harmful Preservatives, Adjuvants, Additives, or Residuals?. Pediatrics December 2003; 112 (6): 1394–1397. 10.1542/peds.112.6.1394
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