Win Tin1 eloquently articulated in his editorial “Oxygen Therapy: 50 Years of Uncertainty” that neonatal care providers do not understand how best to use oxygen in the most vulnerable premature infants despite >50 years of oxygen therapy in neonatal medicine.1 We do not understand optimal oxygenation management in extremely low gestational age neonates (<28 weeks’ gestation), because we do not know what are safe and effective upper and lower limits of oxygen levels or saturation ranges in both the early and later neonatal courses.1–7 There has been no implementation of the most powerful tool in clinical research, the randomized, controlled trial, to resolve the uncertainty since the early clinical trials in the 1950s.8–15 No randomized control trial has clarified the relation between retinopathy of prematurity (ROP) and blood oxygen (Pao2), transcutaneous oxygen (tco2), or oxygen saturation...
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December 2003
Commentaries|
December 01 2003
Resolving Our Uncertainty About Oxygen Therapy
Cynthia H. Cole, MD, MPH;
Cynthia H. Cole, MD, MPH
Division of Newborn Medicine
The Floating Hospital for Children
Tufts University School of Medicine
Boston, MA 02111
Pulse Oximetry Saturation Trial for Prevention of Retinopathy of Prematurity (POST ROP) Planning Study Group
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Kenneth W. Wright, MD;
Kenneth W. Wright, MD
Cedars-Sinai Medical Center
Keck School of Medicine
University of Southern California
Los Angeles, CA 90048
POST ROP Planning Study Group
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William Tarnow-Mordi, MD;
William Tarnow-Mordi, MD
University of Sydney at Westmead
New South Whales 2145, Australia
POST ROP Planning Study Group
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Dale L. Phelps, MD
Dale L. Phelps, MD
University of Rochester School of Medicine and Dentistry
Rochester, NY 14642
POST ROP Planning Study Group
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Address correspondence to Cynthia H. Cole, MD, MPH, Division of Newborn Medicine, Floating Hospital for Children, Tufts-New England Medical Center, 750 Washington St, Boston, MA 02111. E-mail: ccole@tufts-nemc.org
Pediatrics (2003) 112 (6): 1415–1419.
Article history
Received:
January 13 2003
Accepted:
May 28 2003
Citation
Cynthia H. Cole, Kenneth W. Wright, William Tarnow-Mordi, Dale L. Phelps; Resolving Our Uncertainty About Oxygen Therapy. Pediatrics December 2003; 112 (6): 1415–1419. 10.1542/peds.112.6.1415
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