To the Editor.

We feel relieved after reading the paper by Pool et al and the VAERS Team on the prevalence of gelatin allergy in the United States. They conducted a retrospective analysis after measles-mumps-rubella (MMR) vaccination. Among 26 cases of anaphylaxis, only 6 (27%) were positive for anti-gelatin IgE antibodies. The rate of anaphylactic reactions reported to the VAERS is 1.8 per 1 million doses, and no substantial increase in number of reported allergic events after MMR was observed since the introduction of gelatin-containing diptheria-tetanus-acellular pertussis vaccine (DTaP) in 1997. We reported that the cases of anaphylaxis or urticaria showed high positive rates of anti-gelatin IgE antibodies, and we speculated the causal relationship of the sensitization by gelatin-containing DTaP. Discontinuation of gelatin-containing DTaP reduced the incidence of anaphylaxis after 1999, and we have no report of anaphylaxis after vaccination with live virus vaccines containing hydrolyzed...

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