Although rotavirus vaccines are known to be shed in stools, transmission of vaccine-derived virus to unvaccinated contacts resulting in symptomatic rotavirus gastroenteritis has not been reported to our knowledge. We document here the occurrence of vaccine-derived rotavirus (RotaTeq [Merck and Co, Whitehouse Station, NJ]) transmission from a vaccinated infant to an older, unvaccinated sibling, resulting in symptomatic rotavirus gastroenteritis that required emergency department care. Results of our investigation suggest that reassortment between vaccine component strains of genotypes P7[5]G1 and P1A[8]G6 occurred during replication either in the vaccinated infant or in the older sibling, raising the possibility that this reassortment may have increased the virulence of the vaccine-derived virus. Both children remain healthy 11 months after this event and are without underlying medical conditions.
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February 2010
Case Reports|
February 01 2010
Sibling Transmission of Vaccine-Derived Rotavirus (RotaTeq) Associated With Rotavirus Gastroenteritis
Daniel C. Payne, PhD, MSPH;
aEpidemiology Branch and
Address correspondence to Daniel C. Payne, PhD, MSPH, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, MS-A47, Atlanta, GA 30333. E-mail: [email protected]
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Kathryn M. Edwards, MD;
Kathryn M. Edwards, MD
bDepartment of Pediatrics, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee
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Michael D. Bowen, PhD;
Michael D. Bowen, PhD
cGastroenteritis and Respiratory Viruses Laboratory Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia; and
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Erin Keckley, RN;
Erin Keckley, RN
bDepartment of Pediatrics, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee
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Jody Peters, MS;
Jody Peters, MS
bDepartment of Pediatrics, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee
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Mathew D. Esona, PhD;
Mathew D. Esona, PhD
cGastroenteritis and Respiratory Viruses Laboratory Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia; and
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Elizabeth N. Teel, BS;
Elizabeth N. Teel, BS
cGastroenteritis and Respiratory Viruses Laboratory Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia; and
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Diane Kent, RN;
Diane Kent, RN
bDepartment of Pediatrics, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee
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Umesh D. Parashar, MBBS, MPH;
Umesh D. Parashar, MBBS, MPH
aEpidemiology Branch and
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Jon R. Gentsch, PhD
Jon R. Gentsch, PhD
cGastroenteritis and Respiratory Viruses Laboratory Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia; and
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Address correspondence to Daniel C. Payne, PhD, MSPH, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, MS-A47, Atlanta, GA 30333. E-mail: [email protected]
FINANCIAL DISCLOSURE: The authors have indicated they have no financial relationships relevant to this article to disclose.
Pediatrics (2010) 125 (2): e438–e441.
Article history
Accepted:
November 20 2009
Citation
Daniel C. Payne, Kathryn M. Edwards, Michael D. Bowen, Erin Keckley, Jody Peters, Mathew D. Esona, Elizabeth N. Teel, Diane Kent, Umesh D. Parashar, Jon R. Gentsch; Sibling Transmission of Vaccine-Derived Rotavirus (RotaTeq) Associated With Rotavirus Gastroenteritis. Pediatrics February 2010; 125 (2): e438–e441. 10.1542/peds.2009-1901
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