In the last decade, universal newborn screening (NBS) has entered a new era of promise and controversy. With the use of tandem mass spectroscopy, states have substantially increased the number of conditions included in mandatory NBS programs.1 This expansion has mostly followed recommendations from an expert panel commissioned by the Maternal and Child Health Bureau, which proposed mandated screening for a core panel of 29 conditions and suggested that 25 additional conditions be reported to families, although accepted treatments are not yet available.2 The President's Council on Bioethics3 criticized the recommendations, arguing that mandated NBS should be restricted to conditions that adhere closely to Wilson and Jungner's traditional principles for screening,4 especially the availability of treatment that is accepted as effective and accessible to patients. Others have countered that exclusive focus on treatment of the infant ignores other potential benefit to families and society and that...
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March 2010
Pediatrics Perspectives|
March 01 2010
The Lure of Treatment: Expanded Newborn Screening and the Curious Case of Histidinemia
Jeffrey P. Brosco, MD, PhD;
aDepartment of Pediatrics, University of Miami, Miller School of Medicine, Miami, Florida; and
Address correspondence to Jeffrey P. Brosco, MD, PhD, PO Box 016820 (D-820), Miami, FL 33101. E-mail: jbrosco@miami.edu
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Lee M. Sanders, MD, MPH;
Lee M. Sanders, MD, MPH
aDepartment of Pediatrics, University of Miami, Miller School of Medicine, Miami, Florida; and
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Robin Dharia, BS;
Robin Dharia, BS
aDepartment of Pediatrics, University of Miami, Miller School of Medicine, Miami, Florida; and
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Ghislaine Guez, BS;
Ghislaine Guez, BS
aDepartment of Pediatrics, University of Miami, Miller School of Medicine, Miami, Florida; and
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Chris Feudtner, MD, PhD, MPH
Chris Feudtner, MD, PhD, MPH
bDivision of General Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
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Address correspondence to Jeffrey P. Brosco, MD, PhD, PO Box 016820 (D-820), Miami, FL 33101. E-mail: jbrosco@miami.edu
The authors have indicated they have no financial relationships relevant to this article to disclose.
Pediatrics (2010) 125 (3): 417–419.
Article history
Accepted:
December 18 2009
Citation
Jeffrey P. Brosco, Lee M. Sanders, Robin Dharia, Ghislaine Guez, Chris Feudtner; The Lure of Treatment: Expanded Newborn Screening and the Curious Case of Histidinemia. Pediatrics March 2010; 125 (3): 417–419. 10.1542/peds.2009-2060
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