We report here the case of a child with a known muscular abnormality and susceptibility to malignant hyperthermia who abruptly died after receiving a therapeutic dose of ondansetron. Also, we discuss the pharmacodynamic relationship of ondansetron to malignant hyperthermia in a susceptible host.
Administration of Ondansetron Is Associated With Lethal Outcome
FINANCIAL DISCLOSURE: The authors have indicated they have no financial relationships relevant to this article to disclose.
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Blanca Gener, Jarrett M. Burns, Susanne Griffin, Edward W. Boyer; Administration of Ondansetron Is Associated With Lethal Outcome. Pediatrics June 2010; 125 (6): e1514–e1517. 10.1542/peds.2009-2795
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