We report here 2 pediatric cases of multidrug-resistant (MDR) tuberculosis (TB) that were observed in Italy. Both families came from an Eastern European country, which is notably an area with a high prevalence of MDR TB. An increase of new cases of MDR TB in developed countries is expected over the next years because of migratory flow, and specific measures and strategies need to be taken to prevent the propagation and dissemination of MDR TB. An efficacious treatment including linezolid and moxifloxacin was administered for 13 months in 1 case. No adverse reactions were detected during close child monitoring. Linezolid and newer fluoroquinolones such as moxifloxacin have been reported to be effective for MDR-TB treatment in adults. On the contrary, there is limited available evidence regarding the effectiveness and safety of these drugs in infants and children with MDR TB. The use of second-line drugs not approved for use in children may be necessary to treat a life-threatening disease such as MDR TB, but it requires careful monitoring to quickly recognize the occurrence of dose- and duration-dependent adverse drug reactions.
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November 2010
Case Reports|
November 01 2010
Two Pediatric Cases of Multidrug-Resistant Tuberculosis Treated With Linezolid and Moxifloxacin
Michele Pinon, MD;
aClinic of Infectious Diseases, Department of Pediatrics, University of Turin, Regina Margherita Children's Hospital, Turin, Italy;
Address correspondence to Michele Pinon, MD, Regina Margherita Children's Hospital, Piazza Polonia 94, 10126 Turin, Italy. E-mail: michele.pinon@gmail.com
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Carlo Scolfaro, MD;
Carlo Scolfaro, MD
aClinic of Infectious Diseases, Department of Pediatrics, University of Turin, Regina Margherita Children's Hospital, Turin, Italy;
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Elisabetta Bignamini, MD;
Elisabetta Bignamini, MD
bDepartment of Pneumology, Regina Margherita Children's Hospital, Turin, Italy; and
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Giorgio Cordola, MD;
Giorgio Cordola, MD
bDepartment of Pneumology, Regina Margherita Children's Hospital, Turin, Italy; and
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Irene Esposito, MD;
Irene Esposito, MD
bDepartment of Pneumology, Regina Margherita Children's Hospital, Turin, Italy; and
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Rosangela Milano, MD;
Rosangela Milano, MD
cMicrobiology/Virology Laboratory, Department of Infectious Diseases, University of Turin, Amedeo di Savoia Hospital, Turin, Italy
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Federica Mignone, MD;
Federica Mignone, MD
aClinic of Infectious Diseases, Department of Pediatrics, University of Turin, Regina Margherita Children's Hospital, Turin, Italy;
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Chiara Bertaina, MD;
Chiara Bertaina, MD
aClinic of Infectious Diseases, Department of Pediatrics, University of Turin, Regina Margherita Children's Hospital, Turin, Italy;
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Pier-Angelo Tovo, MD
Pier-Angelo Tovo, MD
aClinic of Infectious Diseases, Department of Pediatrics, University of Turin, Regina Margherita Children's Hospital, Turin, Italy;
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Address correspondence to Michele Pinon, MD, Regina Margherita Children's Hospital, Piazza Polonia 94, 10126 Turin, Italy. E-mail: michele.pinon@gmail.com
FINANCIAL DISCLOSURE: The authors have indicated they have no financial relationships relevant to this article to disclose.
Pediatrics (2010) 126 (5): e1253–e1256.
Article history
Accepted:
July 26 2010
Citation
Michele Pinon, Carlo Scolfaro, Elisabetta Bignamini, Giorgio Cordola, Irene Esposito, Rosangela Milano, Federica Mignone, Chiara Bertaina, Pier-Angelo Tovo; Two Pediatric Cases of Multidrug-Resistant Tuberculosis Treated With Linezolid and Moxifloxacin. Pediatrics November 2010; 126 (5): e1253–e1256. 10.1542/peds.2009-2172
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