We review here 7 cases of neonatal transfusion-associated babesiosis at a NICU in the northeast United States. Transfusion from 2 infected units of blood resulted in the 7 cases described. The clinical presentation was highly variable in this cohort; the extremely low birth weight neonates were the most severely affected. Antibiotic therapy was effective in neonates with mild and asymptomatic infection; however, double-volume exchange blood transfusion with prolonged multidrug treatment was required for the 2 most severe cases. The risk of Babesia microti infection is not eliminated through current blood-bank practices. Neonatologists in endemic areas should have a high index of suspicion for babesiosis in premature infants exposed to blood transfusions.
Clinical Presentation and Treatment of Transfusion-Associated Babesiosis in Premature Infants
FINANCIAL DISCLOSURE: The authors have indicated they have no financial relationships relevant to this article to disclose.
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Kari A. Simonsen, Joseph I. Harwell, Shabnam Lainwala; Clinical Presentation and Treatment of Transfusion-Associated Babesiosis in Premature Infants. Pediatrics October 2011; 128 (4): e1019–e1024. 10.1542/peds.2010-0502
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