We have received 4 letters to the editor1–4  regarding the recently published clinical report from the Committee on Fetus and Newborn (COFN) titled “Management of Neonates With Suspected or Proven Early-Onset Sepsis,” which raise a number of important issues. Like the authors of these letters, we are concerned about unnecessary evaluations for sepsis and treatment of asymptomatic infants for an inappropriate length of time. The dangers of prolonged antibiotic therapy in the preterm population are well described.6–8  Neither the Centers for Disease Control and Prevention (CDC) guideline on group B streptococcal disease (GBS) nor the COFN clinical report on early-onset sepsis addresses the duration of antibiotic therapy. Furthermore, although there are data to support which groups of high-risk infants should receive empirical antibiotics, there are only observational data regarding the duration of antibiotic therapy in late-preterm and term infants10,11...

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