This case report describes a preterm newborn infant who was treated with a single dose of rasburicase for an increase in uric acid level. He died on the third day as a result of complications of hemolysis, which appeared to be precipitated by rasburicase. The patient’s death was preceded by progressive respiratory insufficiency, lactic acidosis, and hyperbilirubinemia, culminating in refractory hypoxia and hypotension. A postmortem assay for glucose-6-phosphate dehydrogenase showed deficiency and the glucose-6-phosphate dehydrogenase Mediterranean genotype.
Lethal Effect of a Single Dose of Rasburicase in a Preterm Newborn Infant
FINANCIAL DISCLOSURE: Drs Zaramella and De Salvia served as paid expert witnesses in the case reported in this article; the other authors have indicated they have no financial relationships relevant to this article to disclose.
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Patrizia Zaramella, Alessandra De Salvia, Martina Zaninotto, Maura Baraldi, Giovanni Capovilla, Domenico De Leo, Lino Chiandetti; Lethal Effect of a Single Dose of Rasburicase in a Preterm Newborn Infant. Pediatrics January 2013; 131 (1): e309–e312. 10.1542/peds.2011-1580
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