To identify risk factors for reactions to peanuts (PN) and tree nuts (TN) on first known ingestion among sensitized children.

Children ages 3 to 16 years who were sensitized to PN and/or TN undergoing an oral food challenge to PN and/or TN.

Investigators conducted a retrospective case study of sensitized children undergoing PN and/or TN challenge without a history of consumption of the challenge food. Factors relating to food challenge outcome were analyzed.

Ninety-eight food challenges (47 PN and 51 TN) were performed. The challenge outcomes were 29 positive, 67 negative, and 2 equivocal. A positive maternal history of atopy (odds ratio: 3.73 [95% confidence interval: 1.31–10.59]) and specific immunoglobulin E (IgE) >5 kU/L (odds ratio: 3.35 [95% confidence interval: 1.23–9.11]) were associated with increased risk of positive food challenge. Atopic history in other immediate family members was not predictive of challenge outcome. In addition, there was no association between...

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