There is broad recognition of the need for population-based research to assess the safety and efficacy of newborn screening (NBS) for conditions that are not on current panels. However, prospective population-based research poses significant ethical, regulatory, and logistical challenges. In the context of NBS, there have been a variety of approaches that address parental decision-making in pilot studies of new screening tests or conditions. This article presents an ethical and legal analysis of the role of parental permission by the Bioethics and Legal Work Group of the Newborn Screening Translational Research Network created under a contract from the National Institute of Child Health and Human Development to the American College of Medical Genetics and Genomics. Circumstances are outlined in which a waiver of documentation of permission or a waiver of permission may be ethically and legally appropriate in the NBS context. These guidelines do not constitute American Academy of Pediatrics policy.
Parental Permission for Pilot Newborn Screening Research: Guidelines From the NBSTRN
FINANCIAL DISCLOSURE: The authors have indicated they have no financial relationships relevant to this article to disclose.
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Jeffrey R. Botkin, Michelle Huckaby Lewis, Michael S. Watson, Kathryn J. Swoboda, Rebecca Anderson, Susan A. Berry, Natasha Bonhomme, Jeffrey P. Brosco, Anne M. Comeau, Aaron Goldenberg, Edward Goldman, Bradford Therrell, Jill Levy-Fisch, Beth Tarini, Benjamin Wilfond; on behalf of the Bioethics and Legal Work Group of the Newborn Screening Translational Research Network, Parental Permission for Pilot Newborn Screening Research: Guidelines From the NBSTRN. Pediatrics February 2014; 133 (2): e410–e417. 10.1542/peds.2013-2271
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