The use of an 18F-labeled radiopharmaceutical for positron emission tomography (PET) imaging of sympathetic neuronal activity has a tremendous clinical impact because it circumvents the substantial drawbacks of the prototypical imaging agent, 123I-metaiodobenzylguanidine (MIBG). We describe a 14-year-old male patient who had neuroblastoma and underwent 18F-fluoropropylbenzylguanidine (FPBG) PET/computed tomography (CT). We compared the findings of 18F-FPBG PET/CT with those of 123I-MIBG γ scintigraphy. 18F-FPBG PET/CT readily demonstrated a focal lesion in the left tibia, but the lesion was not seen using 123I-MIBG scintigraphy. Surgical resection proved the presence of a neuroblastoma lesion in the left tibia. To the best of our knowledge, our study was the first to use an 18F-labeled radiopharmaceutical for evaluating sympathetic neuronal activity in neuroblastoma. We suggest that 18F-FPBG is a promising PET agent for imaging sympathetic neuronal activity in neuroblastoma.
Case Report of PET/CT Imaging of a Patient With Neuroblastoma Using 18F-FPBG
FINANCIAL DISCLOSURE: The authors have indicated they have no financial relationships relevant to this article to disclose.
- Views Icon Views
- Share Icon Share
- Search Site
Minseok Suh, Hyo Jin Park, Hyoung Soo Choi, Young So, Byung Chul Lee, Won Woo Lee; Case Report of PET/CT Imaging of a Patient With Neuroblastoma Using 18F-FPBG. Pediatrics December 2014; 134 (6): e1731–e1734. 10.1542/peds.2014-1872
Download citation file: