Thirty years ago, the American Academy of Pediatrics, in partnership with practicing pediatricians and leading academicians, founded Pediatric Research in Office Settings (PROS). In what was at the time a transformative insight, they understood that research in primary care practice settings, developed and conducted in collaboration between pediatricians in community practice and researchers, would lead to relevant and feasible studies that provide an evidence base to improve primary care practice. PROS was groundbreaking in declaring in its rules of governance that practitioners would determine which studies would be launched. Since then, PROS structure has effectively evolved to facilitate the translation of study findings into American Academy of Pediatrics practice guidelines and policies and the fulfillment of the network’s mission “to improve the health of children and enhance primary care practice by conducting and fostering national collaborative practice-based research.”

PROS began with descriptive studies of unanswered questions in pediatrics (the first...

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