Background: Acute kidney injury (AKI), a common complication of pediatric heart transplant (HT), is associated with increased morbidity and mortality. The perioperative hemodynamic alterations associated with postoperative AKI are not well studied in children. The evaluation of high-fidelity, continuous hemodynamic monitoring data in the intensive care unit (ICU) allows for improved characterization of potentially modifiable physiologic variables associated with postoperative AKI. The primary objective of this study was to evaluate the association between perioperative clinical variables and post-operative hemodynamic indices available in the first 12 hours after surgery with development of severe AKI after pediatric HT. Methods: We performed a retrospective study of all patients who underwent HT at a single, quaternary care pediatric institution between 1/2016-11/2019. Perioperative variables as well as hemodynamic indices within the first 12 hours post HT were collected as candidate predictors of outcome. We planned to investigate postoperative continuous pulse pressure variation (PPV), and thus...

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