To assess the clinical relevance of specific immunoglobulin E (IgE) cutoffs for aeroallergens in children.

The population studied includes 6-year-old Danish children in the Copenhagen Prospective Study on Asthma in Childhood in 2000 and 2010.

The distribution of 5 common aeroallergens (house dust mite [HDM], cat, dog, grass, and birch) were assessed among children in these cohorts at 6 years old. Levels were compared between the entire population studied and children with pediatrician-diagnosed allergic rhinitis.

The median value of specific immunoglobulin E (sIgE) in children varied across groups; all children had a median sIgE of 0.14 (HDM), 0.06 (cat), 0.07 (dog), 0.33 (grass), and 0.2 (birch) kUA/L; symptomatic children with rhinitis had a sIgE of 6.29 (HDM), 1.41 (cat), 5.73 (dog), 2.43 (grass), and 1.97 (birch) kUA/L. In symptomatic children, the median values were higher and had increased variation. There was significant overlap between the 2 sets, with high IgE...

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