To determine the role of vitamin D supplementation as adjunct therapy in improving pediatric asthma control.

Children aged 6 to 11 years with moderate persistent asthma (defined as step 3 per Global Initiative for Asthmas [GINA] guidelines) were enrolled. Individuals with coexisting pulmonary, cardiac, renal, and/or endocrine conditions that contributed to vitamin D deficiency or parathyroid disease and/or required vitamin D or calcium supplements in the previous 3 months were excluded.

This 3-month randomized blinded placebo-controlled trial was conducted at a tertiary care hospital in Western India. Baseline clinical information was recorded, spirometry and fractional exhaled nitric oxide (FeNO) were performed as per American Thoracic Society and European Respiratory Society recommendations, and serum 25(OH)D level was measured. Subjects were randomly assigned to 2000 IU per day of vitamin D or placebo. Spirometry, FeNO, and a venous blood sample were repeated at 3 months post enrollment. During the study period, subjects...

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