In this issue of Pediatrics, Brewster et al present an analysis of pediatric clinical trials registered in ClinicalTrials.gov from 2007 to 2020. Focusing on interventional trials enrolling only children (up to 17 years), the authors examined rates of trial discontinuation and results reporting, including factors associated with these outcomes. Their analysis spans an extended period and encompasses a broad selection of trial designs and interventions, providing information on trends over time across the pediatric clinical trial enterprise. Their findings serve to highlight several key areas requiring continued focus and provide a benchmark for ongoing monitoring and assessment.

The authors found that approximately 11% of trials were discontinued, with a modest reduction in this rate over the study period. Over one-third failed due to poor participant accrual, which was the most common reason for discontinuation irrespective of the type of trial sponsor. Prior studies have reported a wide range...

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