New York State began newborn screening (NBS) for Krabbe Disease (KD) in 2006. Since then, testing and screening algorithms have advanced and 9 additional states have added KD to their NBS panels. To date >6 700 000 newborns have benefited from NBS for KD and 23 newborns with infantile KD (IKD) were identified. In their article, Vergano et al described the processes used by the Commonwealth of Virginia Newborn Screening Advisory Council to decide whether KD should be included in the state’s NBS panel along with their decision not to include it. We believe that the Commonwealth of Virginia Newborn Screening Advisory Council failed to consider advances in screening tests and algorithms, disease definitions, and follow-up guidelines, or recent reports of efficacy of early hematopoietic stem cell transplantation for IKD.

Vergano et al highlighted, “the lack of consensus regarding the definition of EIKD and later onset forms,” even among...

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