Hepatitis C virus (HCV) infection continues to be a major national public health problem and is targeted for domestic and global elimination. Driven by the ongoing opioid epidemic, HCV incidence has been rising in the United States over the past decade, with highest infection rates among young adults including women of childbearing age. This is significant because if these young adults with HCV viremia get pregnant, their infants are perinatally exposed to the virus. In 2020, as part of a strategy to increase testing of all adults, the Centers for Disease Control and Prevention (CDC) recommended universal HCV antibody screening with every pregnancy, a critical first step to improve maternal health and enhance identification of infants at risk for HCV. With a 3% to 8% risk, perinatal transmission is still the most common route of HCV infection among children, and an increasing number of infants have been infected...

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