Immunologic studies of a patient with agammaglobulinemia are reported. The delayed type of hypersensitivity was normally produced in response to antigenic stimuli, but circulating antibodies of the gamma globulin fraction of the serum were not. It is postulated that delayed hypersensitivity is responsible for the apparent immunity developed against measles and chicken pox. The tuberculin response is independent of gamma globulin in the serum.
The family tree of first cousins with congenital agammaglobulinemia is presented and supports the concept that the disease is a sex-linked recessive trait appearing only in male children.