Judging by the volume of advertising and of sales, tranquilizing drugs have been widely employed during the past several years. Physicians in general have not been fearful of adverse reactions and promotional literature has emphasized their essential harmlessness. Reactions, especially with large dosage, have been reported (Hollister, L. E.: New England J. Med., 257:170, 1957) but are best known to pharmacologists and psychiatrists. The pharmaceutical manufacturers have given some warnings but have mostly emphasized the ease with which most of these reactions, when recognized, may be treated.

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