Hydrogen peroxide, administered rectally or intraperitoneally, has been reported to improve systemic oxygenation. Therefore, the effectiveness of intraperitoneal administration of hydrogen peroxide, 0.3%, was investigated in hypoxic rabbits as a possible method of supplementation of oxygenation in respiratory distress syndrome or in the postoperative cardiac patient. Although hydrogen peroxide initially caused a slight increase in arterial oxygen saturation, this increase was brief and was followed by a marked fall in arterial oxygen saturation. Hypotension occurred in all rabbits. It is suggested that the intraperitoneal administration of hydrogen peroxide for the purpose of extrapulmonary oxygenation is largely ineffective and hazardous, and it probably should not be attempted in the human subject.

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