One hundred seventy-two normal Thai infants and children were studied to determine the prevalence of lactose malabsorption and lactase deficiency. These abnormalities became manifest after infancy, and by age 2 years virtually all children studied were abnormal. Sucrase and maltase activities and sucrose and glucose absorption were normal in most. Calculation of ratios of median maltase/lactase, sucrase/lactase, and maltase/sucrase activities also indicated the major abnormality to be isolated lactase deficiency. Lactose malabsorption appeared earlier in life in a group of normal institution Thai children compared to a group of village children. This suggests that environmental factors may be important in the pathogenesis of lactase deficiency in Thai children, although genetic influences cannot be excluded.
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April 1969
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April 01 1969
ACQUIRED LACTOSE MALABSORPTION IN THAI CHILDREN
Gerald T. Keusch;
Gerald T. Keusch
Department of Clinical Research, SEATO Medical Research Laboratory, Bangkok, Thailand and the Department of Gastroenterology, Walter Reed Army Institute of Research, Washington, D.C.
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Frank J. Troncale;
Frank J. Troncale
Department of Clinical Research, SEATO Medical Research Laboratory, Bangkok, Thailand and the Department of Gastroenterology, Walter Reed Army Institute of Research, Washington, D.C.
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Louis H. Miller;
Louis H. Miller
Department of Clinical Research, SEATO Medical Research Laboratory, Bangkok, Thailand and the Department of Gastroenterology, Walter Reed Army Institute of Research, Washington, D.C.
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Varuni Promadhat;
Varuni Promadhat
Department of Clinical Research, SEATO Medical Research Laboratory, Bangkok, Thailand and the Department of Gastroenterology, Walter Reed Army Institute of Research, Washington, D.C.
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Pearl R. Anderson
Pearl R. Anderson
Department of Clinical Research, SEATO Medical Research Laboratory, Bangkok, Thailand and the Department of Gastroenterology, Walter Reed Army Institute of Research, Washington, D.C.
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Pediatrics (1969) 43 (4): 540–545.
Article history
Received:
July 19 1968
Accepted:
November 15 1968
Citation
Gerald T. Keusch, Frank J. Troncale, Louis H. Miller, Varuni Promadhat, Pearl R. Anderson; ACQUIRED LACTOSE MALABSORPTION IN THAI CHILDREN. Pediatrics April 1969; 43 (4): 540–545. 10.1542/peds.43.4.540
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