In the summer and fall of 1968, during clinical rubella vaccine trials, clinical and laboratory surveillance of acute exanthematous illnesses was carried out. During this period, four children with acute transitory hemangioma-like lesions were noted; ECHO 25 virus was isolated from two of these patients and ECHO 32 was recovered from the other two children. All four children had four- fold or greater neutralizing antibody titer rises to their respective viruses. It is suggested that the individual lesions of the reported exanthems have a pathogenesis similar to other enteroviral maculopapular eruptions, except that vascular dilatation is arteriolar as well as capillary.

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