An increase in the incidence of hernia, hydrocele, and undescended testis was observed in males with cystic fibrosis, and to a lesser degree in male siblings and fathers. This increased incidence may be associated with the gene for cystic fibrosis and may be considered a reflection of altered embryogenesis of the wolffian derived structures. The finding of an absent vas deferens at hernia repair or orchiopexy in a child or young adult should suggest the possibility of cystic fibrosis.

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