Despite 17 pregnancies, Queen Anne left no surviving children. The unfortunate results of her pregnancies are consistent with listeriosis in four of its manifestations: habitual abortion, stillbirth, neonatal death, and postnatal meningitis with residual hydrocephalus. Because Anne was childless, the Crown passed to the House of Hanover. Parliament made use of this situation to assume the initiative in government which it has maintained to the present.

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