A 5-year-old boy with persistent nocturnal enuresis was found to be infected with coagulase-negative staphylococci. Evaluation showed major urologic abnormalities with significant histologic changes. Review of the literature revealed a paucity of data relative to the pathogenicity of coagulase-negative staphylococci in urinary tract disease. The present case emphasizes that association, calls attention to the significance of persistent nocturnal enuresis and suggests an approach to the evaluation of the child with enuresis.

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