The effect of home mist tent therapy in cystic fibrosis was reexamined using the measurement of maximum expiratory flow volume (MEFV) curves, forced expiratory volume (FEV1), and vital capacity (VC) in 16 patients every 2 weeks during a period of 4 to 5 months. In half of the patients the studies were made during an initial period of 8 to 12 weeks off and then a similar period on nocturnal mist tent therapy; in the other half the test conditions were reversed. No evidence of improvement in ventilatory function was found in these patients during the use of a mist tent; instead there was a small but significant decline in their ventilatory function. Home visits were made and bacterial contamination of mist tent equipment was noted in more than two-thirds of the tents in spite of careful cleaning instructions to the parents. The MEFV curve was found to be a simple yet sensitive test of evaluating lower airway obstruction in cystic fibrosis.

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