Clinical observations, coagulation studies, and analysis of simultaneously obtained samples of lung effluent and arterial or venous blood for hematocrit and protein composition as determined by gel filtration were performed on 15 infants collapsing with blood stained liquid flowing from their tracheas. The results indicate that (1) The lung effluent was in most cases hemorrhagic edema fluid and not whole blood. (2) The most important precipitating factor was probably acute left ventricular failure due to asphyxia, although other factors favoring increased filtration of liquid from pulmonary capillaries or causing lung damage may have played a contributory role in pathogenesis. (3) Coagulation disorders probably served to exacerbate the condition but not initiate it.
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February 1973
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February 01 1973
PATHOGENESIS OF HEMORRHAGIC PULMONARY EDEMA AND MASSIVE PULMONARY HEMORRHAGE IN THE NEWBORN
Valerie A. Cole;
Valerie A. Cole
Departments of Paediatrics and Clinical Haematology, University College Hospital Medical School, London, and the Department of Child Health, University of Southampton Medical School, Southampton, England
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I. C. S. Normand;
I. C. S. Normand
Departments of Paediatrics and Clinical Haematology, University College Hospital Medical School, London, and the Department of Child Health, University of Southampton Medical School, Southampton, England
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E. O. R. Reynolds;
E. O. R. Reynolds
Departments of Paediatrics and Clinical Haematology, University College Hospital Medical School, London, and the Department of Child Health, University of Southampton Medical School, Southampton, England
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R. P. A. Rivers
R. P. A. Rivers
Departments of Paediatrics and Clinical Haematology, University College Hospital Medical School, London, and the Department of Child Health, University of Southampton Medical School, Southampton, England
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Pediatrics (1973) 51 (2): 175–187.
Article history
Received:
July 03 1972
Accepted:
September 22 1972
Citation
Valerie A. Cole, I. C. S. Normand, E. O. R. Reynolds, R. P. A. Rivers; PATHOGENESIS OF HEMORRHAGIC PULMONARY EDEMA AND MASSIVE PULMONARY HEMORRHAGE IN THE NEWBORN. Pediatrics February 1973; 51 (2): 175–187. 10.1542/peds.51.2.175
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