Drs. Sack and DeLamater quote our paper as confirming the observation that hypothyroidism develops in growth hormone (GH)-deficient patients upon the institution of GH therapy. This statement is incorrect since no significant change in thyroid function was observed during several months of GH therapy. In fact, our data may be interpreted as indicating that some GH-deficient patients have a state of hypothyroidism undetectable by measurement of serum total and free thyroxine levels prior to the institution of GH replacement.

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