I fully agree with Dr. Smith's concern about the use of ointments containing iodochlorhydroxyquin (clioquinol, Vioform) (Pediatrics 57:163, January 1976). In a child with generalized psoriasis locally treated with an iodochlorhydroxyquin ointment, 18.1 mg/100 ml of the conjugated (glucuronic acid ester) drug was found in the urine.1 After the first suspicion that iodochlorhydroxyquin could result in optic atrophy,2 several reports from different countries have appeared. Furthermore, the SMON (subacute myelo-optico neuropathy) catastrophe with thousands of victims in Japan has brutally shown the dangers of this drug.

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