Acetaminophen overdose was studied in 416 patients as part of a nationwide multiclinic open study. Twenty-seven percent of the patients were toxic by plasma acetaminophen level. The 12- to 21-year-old age group had the highest incidence of toxic blood levels (47%). Children under age 5 had the mildest toxicity of any age group; only two of 16 patients had toxic blood levels. No relationship to subsequent Reye's syndrome could be demonstrated. Acetylcysteine is a safe, effective treatment if administered within the first ten hours; it has some efficacy with no toxicity if used after ten hours. Acetylcysteine has advantages over both cysteamine and methionine. All patients in this study recovered with no sequelae.
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Articles| November 01 1978
Acetaminophen Overdose: Incidence, Diagnosis, and Management in 416 Patients
Barry H. Rumack;
Robert G. Peterson
Pediatrics (1978) 62 (5s): 898–903.
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Barry H. Rumack, Robert G. Peterson; Acetaminophen Overdose: Incidence, Diagnosis, and Management in 416 Patients. Pediatrics November 1978; 62 (5s): 898–903. 10.1542/peds.62.5S.898
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