Reports about the response of arthritis associated with agammaglobulinemia to conventional amounts of exogenous γ-globulin have been controversial.1-3 It appears from some of these reports3 that more intensive therapy with exogenous γ-globulin is required for accomplishing remission of joint symptoms that is necessary for control of infections. Pabst and Gelpke (Pediatrics 61:306, 1978) suggested that a certain level of serum IgG should be achieved and maintained for remission. We report similar results in one of our patients with arthritis and congenital agammaglobulinemia.

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