I would like to add my short comments to the concise commentary of Phelps1 on vitamin E. In addition to the mentioned several conditions related to vitamin E metabolism, probable vitamin E deficiency in the pathogenesis of thrombocytosis in Caffey's disease2 should be remembered by the pediatricians. We have seen such a case recently.3 Improvement of erythrocyte survival in chronic hemolyzing G-6 PD and glutathione synthetase deficiency with high doses of vitamin E seems to be promising approach in the treatment of these patients.4

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